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KMID : 1143120150050030170
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Asia Pacific Allergy
2015 Volume.5 No. 3 p.170 ~ p.176
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Repeat oral food challenges in peanut and tree nut allergic children with a history of mild/moderate reactions
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Wainstein Brynn Kevin
Saad Rebecca Anne
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Abstract
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Background: In peanut and tree nut allergic children a history of anaphylaxis is associated with subsequent severe reactions.
Objective: We aimed to prospectively rechallenge peanut and tree nut allergic children with a history of mild/moderate reactions to assess their allergy over time.
Methods: In this cohort study peanut and tree nut allergic children with a history of mild/moderate reactions during a controlled oral challenge were invited to have a follow-up oral challenge to the same food at least 1 year later.
Results: Twenty-six children participated in the study. The mean time interval between the first and second challenge for all participants was 35.5 months. Peanut or tree nut allergy resolved in 38.5% of participants. Those with persistent peanut or tree nut allergy showed a decrease in their reaction threshold and/or increased severity in 81% of cases. There were no demographic features or skin test results that were predictive of changes in severity over time.
Conclusion: Peanut and tree nut allergic children with a history of mild/moderate reactions who remained allergic demonstrated a high rate of more severe reactions and/or reduced thresholds upon rechallenge over a year later, however, the rate of resolution of allergy in this group may be higher than previously reported.
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KEYWORD
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Peanut Hypersensitivity, Nut Hypersensitivity, Anaphylaxis, Child
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